The regulatory requirements are constantly increasing in the medicines manufacturing sphere, which is reflected in the good manufacturing practice rules.The changes in the GMP regulations relating to personnel, premises and equipment, production, quality control, complaints, quality defects and product recalls, as well as a new version Tofu of qual
Refining a Digital Therapeutic Platform for Home Care Agencies in Dementia Care to Elicit Stakeholder Feedback: Focus Group Study With Stakeholders
BackgroundPersons living with dementia require increasing levels of care, and the care model has evolved.The Centers for Medicare and Medicaid Services is transitioning long-term care services from institutional care to home- or community-based services, including reimbursement for nonclinical services.Although home care companies are positioned to
Comparison between the brief seven-item and full eating disorder examination-questionnaire (EDE-Q) in clinical and non-clinical female Norwegian samples
Abstract Background The Eating Disorder Examination-Questionnaire (EDE-Q) is among the most widely used self-report measures of eating disorder (ED) psychopathology.There is a need for brief versions of the EDE-Q that can be used for general assessment and screening purposes.A three-factor 7-item version (EDE-Q7) seems particularly promising but th
Marine Predators Algorithm for Sizing Optimization of Truss Structures with Continuous Variables
In this study, the newly developed Marine Predators Algorithm (MPA) is formulated to minimize the weight of truss structures.MPA is Clock a swarm-based metaheuristic algorithm inspired by the efficient foraging strategies of marine predators in oceanic environments.In order to assess the robustness of the proposed method, three normal-sized structu
Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice.
Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo.However, there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET) mice.The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout animals.